Michael S. Hughes, MD

Dr. Michael Hughes is an attending physician and Assistant Professor practicing at Columbia University Irving Medical Center. He received his A.B. in Classics magna cum laude from Harvard College and his MD cum laude from Harvard Medical School. He completed his Internal Medicine residency at the Johns Hopkins Bayview Medical Center and Hematology/Oncology fellowship at the Columbia University Irving Medical Center. He is a member of the American College of Physicians, the American Medical Association, the American Society of Hematology, and the American Society of Clinical Oncology.
Dr. Hughes' research has explored the interplay between cancer and the immune system. As an undergraduate medical student, he studied immune checkpoint inhibitor-induced gastroenterocolitis. As a Johns Hopkins Physician Scientist Training Pathway Scholar during residency, he investigated outcomes in patients with peripheral T-cell lymphomas after haploidentical blood and marrow transplantation. As an NIH T32-supported fellow, he worked in the Lentzsch Laboratory to develop novel anti-AL amyloidosis fibril therapies. For his contributions, Dr. Hughes was awarded the 2024 ASCO/Conquer Cancer Young Investigator Award and the 2025 Amyloidosis Foundation Research Grant.
Dr. Hughes cares primarily for patients with plasma cell disorders, including multiple myeloma, amyloidosis, MGUS, POEMS syndrome, and Waldenstrom's macroglobulinemia. His current translational research interests focus on machine learning/deep learning-assisted outcome prediction in these diseases and the ongoing development of novel anti-AL amyloidosis fibril strategies.