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The active ingredient sildenafil has not been patented since 2013. Therefore, there are generics of other manufacturers on the market, which are identical in dosage and effect to Viagra. Like the four mentioned original preparations, the generics are of course also prescription-only. The generics are, however, significantly cheaper in price.

Viagra, Cialis, Levitra: Legendary ED Bestsellers At Canadian Pharmacy

Regardless of which drug you are taking, the PDE5 inhibitors all start at the same point. When a sexual stimulus is triggered as stimulation, as a physical reaction, nitric oxide (NO) is released in the cavernosum in the penis. This activates an enzyme that causes cycloGMP to form. This in turn relaxes the smooth muscles in the cavernosum, allows blood to flow in and creates an erection. Another enzyme, phosphodiesterase type 5 (PDE5), breaks down the cycloGMP and the erection disappears again. This is where the PDE5 inhibitors start.

The active ingredients in Viagra, Cialis, Levitra and Spedra prevent the breakdown of cycloGMP, the erection can be maintained so with continued sexual stimulation. The cycloGMP is thus rebuilt time and again, but not degraded, and accumulates in the erectile tissue. The smooth muscles are further relaxed by the enrichment and strengthen the blood flow into the erectile tissue. The erection is thus stronger.

Contrary to public opinion, PDE5 inhibitors are therefore not ‘sexual enhancers’ that increase pleasure or other lifestyle properties, but drugs with a specific effect and the goal of solving a problem. By taking PDE5 inhibitors also no erection is produced, it is strengthened and lasts longer. This also means that a sexual stimulus must be present for the remedies to work. The other parts in the drainage chain to the erection must also be intact, especially the nerve structure.