Holiday Inn Express & Suites Hannibal - Medical Center by IHG

Welcome to Holiday Inn Express & Suites Hannibal - Medical Center, your comfortable base for exploring this storied stretch of northeast Missouri. Our Hannibal hotel places you close to the Mark Twain Boyhood Home & Museum, the adventure-filled Mark Twain Cave, and scenic views along the Mississippi River. Whether you're here for a quick getaway or to experience the charm of historic downtown, this hotel in Hannibal keeps you connected to the area’s most memorable attractions.

Unwind with thoughtful amenities designed to keep your stay easy and enjoyable. Take a dip in the heated indoor pool, stay productive in the dedicated meeting space, or enjoy the convenience of a central location near local businesses and medical centers. Guests also appreciate our 24-hour fitness center, free Wi-Fi, complimentary hot breakfast, and free parking, making it simple to settle in and focus on what matters most.